持续近两个多月的 新型冠状病毒感染的肺炎疫情牵动着 每一个人的心，为了打赢这场疫情防控狙击战， 搞清致病机理，研发抗病毒药物和疫苗 刻不容缓 。 Jena bios c ience 品牌有丰富的抗病毒核苷酸 / 核苷酸类似物，助力 抗 病毒 药物 研发。
抗病毒核苷及核苷酸类似物主要有:
抗病毒 核苷 / 核苷酸类似物可以 通过抑制病毒复制的几个关键过程来抑制病毒繁殖 ， 它们通过与天然的 dNTP/NTP 竞争结合到新的病毒核酸中，从而导致链终止或者诱变。 在细胞培养实验中，可以 用 抗病毒核苷酸的非磷酸化核苷变体，这种核苷酸在细胞内被多种病毒和 / 或宿主激酶 激活 ，从而发挥 (tri) 磷酸化形式的抗病毒作用 。
热销抗病毒核苷
/
核苷酸类似物：
品
牌
货号
品名
规格
Jena Bioscience
NU-1605S
3TCMP
10
μl
(10
mM
)
Jena Bioscience
NU-1605L
3TCMP
5 x 10
μl
(10
mM
)
Jena Bioscience
NU-1606S
3TCTP
5
μl
(10
mM
)
Jena Bioscience
NU-1606L
3TCTP
5 x 5
μl
(10
mM
)
Jena Bioscience
NU-1603S
d4TMP
20
μl
(10
mM
)
Jena Bioscience
NU-1603L
d4TMP
5 x 20
μl
(10
mM
)
Jena Bioscience
NU-1601S
AzTMP
20
μl
(10
mM
)
Jena Bioscience
NU-1601L
AzTMP
5 x 20
μl
(10
mM
)
Jena Bioscience
NU-989S
AzTTP
10
μl
(100
mM
)
Jena Bioscience
NU-989L
AzTTP
5 x 10
μl
(100
mM
)
Jena Bioscience
NU-875
ara-Adenosine-5'-monophosphate (
ara
-AMP)
2 mg
Jena Bioscience
NU-1111S
50
μl
(10
mM
)
Jena Bioscience
NU-1111L
ara-Adenosine-5'-triphosphate (
ara
-ATP)
5 x 50
μl
(10
mM
)
Jena Bioscience
NU-876
Acyclovir-5'-monophosphate
2 mg
Jena Bioscience
NU-877
Acyclovir-5'-triphosphate
2 mg
Jena Bioscience
NU-021-2
Ribavirin-5'-monophosphate
2 mg
Jena Bioscience
NU-1105S
20
μl
(10
mM
)
Jena Bioscience
NU-1105L
Ribavirin-triphosphate
5 x 20
μl
(10
mM
)
Jena Bioscience
N-DN-8234-100
β
-L-2'-Deoxythymidine
100 mg
Jena Bioscience
NU-896S
10
μl
(100
mM
)
Jena Bioscience
NU-896L
6-Aza-UTP
5 x 10
μl
(100
mM
)
Jena Bioscience
NU-974
Tenofovir
100 mg
Jena Bioscience
NU-975
Tenofovir-diphosphate
1 mg
Jena Bioscience
NU-989S
10
μl
(100
mM
)
Jena Bioscience
NU-989L
AzTTP
5 x 10
μl
(100
mM
)
Jena Bioscience
NU-275S
10
μl
Jena Bioscience
NU-275L
Ganciclovir-triphosphate
5 x 10
μl
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参考文献：
1] Huang
at al.
(2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
.
BMC Biochemistry
12:18.
[2] Vaccaro
at al.
(1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP.
Antimicrob. Agents Chemother.
44 (1):217.
[3] Jaju
at al.
(1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer.
J. Biol. Chem.
270 (17):9740.
[4] Furmann
at al.
(1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate.
J. Virol.
29 (2):154.
[5] Muller
at al.
(1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems.
Ann. N.Y. Acad. Sci.
284:34.
[6] Crotty
at al.
(2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen.
Nature Medicine
6 (12):1375.
[7] Ray
at al.
(2009) Metabolism of antiviral nucleosides and nucleotides. In:
Antiviral Research: Strategies in antiviral drug discovery
(LaFemina). ASM Press.
[8] Simons
at al.
(2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics.
Current Topics in Medicinal Chemistry
5:1191.
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